Progression-free survival as a surrogate for overall survival in oncology trials: a methodological systematic review
نویسندگان
چکیده
منابع مشابه
Progression-free survival as a surrogate endpoint for overall survival in glioblastoma: a literature-based meta-analysis from 91 trials
BACKGROUND The aim of this study was to determine correlations between progression-free survival (PFS) and the objective response rate (ORR) with overall survival (OS) in glioblastoma and to evaluate their potential use as surrogates for OS. METHOD Published glioblastoma trials reporting OS and ORR and/or PFS with sufficient detail were included in correlative analyses using weighted linear r...
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The traditional endpoint for assessing efficacy of chemotherapies for advanced/recurrent gastric cancer is overall survival (OS), but OS requires prolonged follow-up. We investigated whether progression-free survival (PFS) is a valid surrogate for OS. Using individual patient data from the GASTRIC meta-analysis, surrogacy of PFS was assessed through the correlation between the endpoints and thr...
متن کاملProgression-free survival as a potential surrogate for overall survival in metastatic breast cancer
BACKGROUND Progression-free survival (PFS) and time to progression (TTP) are frequently used to establish the clinical efficacy of anti-cancer drugs. However, the surrogacy of PFS/TTP for overall survival (OS) remains a matter of uncertainty in metastatic breast cancer (mBC). This study assessed the relationship between PFS/TTP and OS in mBC using a trial-based approach. METHODS WE CONDUCTED ...
متن کاملCombining progression-free survival and overall survival as a novel composite endpoint for glioblastoma trials.
BACKGROUND The use of auxiliary endpoints may provide efficiencies for clinical trial design, but such endpoints may not have intrinsic clinical relevance or clear linkage to more meaningful endpoints. The purpose of this study was to generate a novel endpoint that considers both overall survival (OS) and earlier events such as progression-free survival (PFS) and determine whether such an endpo...
متن کاملInterpretation of meta-analysis evaluating progression-free survival as a surrogate endpoint for overall survival in glioblastoma
Alexander et al recently introduced a different interpretation involving our paper, in which we systematically evaluated glioblastoma clinical trials published from 1991 to the present and demonstrated that progression-free survival (PFS) may be an appropriate surrogate endpoint for overall survival (OS). Although the authors did not raise any methodological and clinical questions directly to u...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2020
ISSN: 0007-0920,1532-1827
DOI: 10.1038/s41416-020-0805-y